Nurosym by numbers
60+
Scientific Partners
3,000,000+
Sessions Completed
0
Serious Adverse Events in studies to date
Nurosym Stories

After couple of weeks I suddenly realised, "I feel like me again." The depressive state has lifted and I have the get up and go, Thank you folks :)

When I got the device, two days later, suddenly I had so much energy, I felt...something is good!

It has exceeded my expectations and I would happily recommend it to anyone with a diagnosed vagus nerve disorder and depressive states/anxious thoughts.

It's an amazing product. Honestly I've seen such a huge difference, I don't have as many days where I'm exhausted I can barely move.

While I can still have bad days, I'm much more stable and less prone to such destructive dips on mood.

I've looked into a number of approaches to reset my nervous system, the one that's given me the most obvious change is Nurosym.
Nurosym FAQs
Our research focuses on how imbalances in the autonomic nervous system may impact overall well-being and daily performance.
We have explored various challenges, including:
- Energy levels and resilience in demanding situations
- Mental clarity, focus, and adaptability
- Digestive balance and daily comfort
- Restful sleep and natural relaxation
- Emotional balance and mood support
- General physical comfort and tension
Our data also suggests that Nurosym supports enhanced learning, sharper memory, and improved focus, promoting overall cognitive wellness.
Additionally, Nurosym has shown potential in encouraging relaxation, supporting mood, promoting restful sleep, and fostering healthy digestive rhythms.
Current investigations are exploring the broader effects of neuromodulation on areas like athletic performance, recovery, and overall vitality.
If you’re unsure whether Nurosym is right for you, consult with your trusted professional or contact our support team by clicking the Support icon at the bottom right of the page.
The timeframe for experiencing the benefits of Nurosym varies by individual. Some may notice changes in just a few days, while for others, it may take a few weeks of consistent use. With regular sessions, Nurosym’s potential to support your well-being becomes increasingly evident over time.
Nurosym is designed with safety and user well-being in mind when used as intended.
- Developed based on extensive scientific research
- Certified for safe use
- Supported by data demonstrating its effectiveness
We recommend reviewing the important safety information provided before use. Thousands of users have utilized Nurosym, and no serious adverse effects have been reported in studies to date.
Nurosym delivers a gentle, soothing sensation, often described as a light vibration or tingling in the ear.
There are no additional costs or fees, only the one-time purchase of the Nurosym.
Please review the instructions for use carefully before using Nurosym. If you have any questions or need additional guidance, consult your health professional or contact Nurosym Care for assistance.
- Use Nurosym only as described in the instructions for use or as directed by your health professional.
- Remove any jewelry, such as earrings, that may interfere with the placement of the electrodes.
- Avoid using Nurosym if the skin on the tragus is broken, cracked, or numb.
By following these guidelines, you can ensure the best possible experience with Nurosym.
Important Safety Information: When selecting a device designed to interact with the nervous system, it’s essential to prioritize safety and scientific validation. Devices claiming to influence the vagus nerve can vary significantly in design and approach, which may affect their performance and reliability. Factors such as waveform precision and site placement are critical to achieving consistent outcomes.
Nurosym is a cutting-edge, non-invasive system supported by extensive research. Over $10 million has been invested in studies, resulting in 50+ publications in leading journals. Nurosym meets high standards of safety and quality, with certifications from regulatory bodies in the EU.
For best results, always choose devices with demonstrated scientific validation and established safety profiles.
For the best experience, we recommend using Nurosym for 1 hour daily. However, some users report noticing benefits with sessions as short as 15 minutes.
Yes, Nurosym is designed to fit seamlessly into your routine, allowing you to use it comfortably while engaging in everyday activities.
No prescription is required to purchase Nurosym. If you’re unsure whether Nurosym is suitable for you, we recommend consulting with your health professional for guidance.
If you use Nurosym daily for 30 days and aren’t completely satisfied, we’ll issue a full refund—no questions asked.
We’re confident in the positive impact Nurosym can have, as shown by research and feedback from users worldwide. Our mission is to support well-being on a global scale, empowering individuals to feel their best.
The refund period is valid for 30 days after purchase and extends an additional 7 days (a total of 37 days after purchase).
To request a refund, simply provide your return tracking code, and we’ll process your request promptly.
Yes! We offer a one-year warranty with every Nurosym device.
Orders are processed and dispatched within 1-3 business days.
Nurosym is shipped via priority tracked and signed couriers, so delivery times will vary based on shipping location. When you checkout, you'll receive an estimated shipping time for your order.
- Nurosym device
- Earpiece
- USB charger
- Case
- Quick start guide
Watch Dr Denef explain how to use Nurosym
Biological Mechanisms Underlying VNS Effects
The therapeutic effects of Nurosym on mood, anxious thoughts, and stress are mediated through complex biological processes involving various neural pathways and neurotransmitter systems.
1. Activation of Brainstem Nuclei:
- Nucleus Tractus Solitarius (NTS): VNS activates the NTS, which is a primary relay center in the brainstem for visceral sensory information.
- Locus Coeruleus (LC): Activation of the LC leads to the release of nоrеріnерhrіnе, a neurotransmitter involved in arousal and mood regulation.
2. Modulation of Neurotransmitter Systems:
- Serotonin (5-HT): VNS increases serotonin levels in the brain, enhancing mood and promoting feelings of well-being.
- Nоrеріnерhrіnе (NE): Elevated nоrеріnерhrіnе levels improve alertness and energy, countering depressive symptoms.
- Gamma-Aminobutyric Acid (GABA): VNS influences GABAergic neurons, promoting inhibitory effects that reduce anxious thoughts and excitability.
- Glutamate: Modulation of glutamatergic transmission can affect neural plasticity and mood regulation.
3. Impact on the Hypothalamic-Pituitary-Adrenal (HPA) Axis:
- VNS can attenuate the stress-induced activation of the HPA axis, leading to reduced cortisol levels and dampening the body's stress response.
- By modulating the HPA axis, VNS helps in normalizing stress hormone levels, thereby reducing anxious thoughts and improving mood.
4. Anti-Inflammatory Effects:
- Cholinergic Anti-Inflammatory Pathway: VNS stimulates the release of acetylcholine, which binds to α7 nicotinic acetylcholine receptors on immune cells, reducing the production of pro-inflammatory cytokines.
- Reduction of Neuroinflammation: Decreased inflammation in the brain can reduce depressive symptoms and improve neuronal function.
5. Enhancement of Neuroplasticity:
- VNS promotes neurogenesis and synaptic plasticity, particularly in the hippocampus, a region associated with memory and mood regulation.
- Increased levels of brain-derived neurotrophic factor (BDNF) have been observed, supporting neuronal growth and resilience.
6. Regulation of Heart Rate Variability (HRV):
- Improved HRV is associated with better emotional regulation and reducing anxious thoughts.
- VNS enhances parasympathetic tone, leading to increased HRV and promoting relaxation.
7. Gut-Brain Axis Interaction:
- The vagus nerve serves as a communication pathway between the gut microbiota and the brain.
- VNS may influence gut health, which in turn can impact mood and stress levels through the production of neuroactive compounds.
Scientific Research
- Natelson, B., Blate, M., & Soto, T. (2022). Transcutaneous vagus nerve stimulation in the treatment of long covid-chronic fatigue syndrome. medRxiv, 2022-11.
- Jackowska M, Koenig J, Vasendova V, Jandackova VK. A two-week course of transcutaneous vagal nerve stimulation improves global sleep: Findings from a randomised trial in community-dwelling adults. Auton Neurosci Basic Clin. 2022 Jul 1
- Geng D, Liu X, Wang Y, Wang J. The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people. PLoS ONE. 2022 Feb 10;17(2):e0263833.
- Geng D, Yang K, Fu Z, Zhang Y, Wang C, An H. Circadian stage-dependent and stimulation duration effects of transcutaneous auricular vagus nerve stimulation on heart rate variability. PLOS ONE. 2022 Nov 3;17(11):e0277090.
- Verbanck P, Clarinval A, Burton F, Corazza F, Nagant C, Cheron G. Transcutaneous Auricular Vagus Nerve Stimulation (tVNS) can Reverse the Manifestations of the Long-COVID Syndrome: A Pilot Study. Advances in Neurology and Neurosciences Research. 2021;
- Thakkar, Vishal, Zoe A. Richardson, Annie Dang, and Tracy Centanni. 2021. “Improvement of Memory-based Reading Recall Using Transcutaneous Auricular Vagus Nerve Stimulation.” PsyArXiv. September 7. doi:10.31234/osf.io/wvsrc.
- Tonsager A. The Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Novel Language Learning. Texas Christian University Library, 2020
- Richardson Z. The Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Reading Comprehension. Texas Christian University Library 2020
- Thakkar VJ, Richardson ZA, Dang A, Centanni TM. The effects of transcutaneous auricular vagus nerve stimulation on reading comprehension. Texas Christian University. 2020
- Noé E, Ferri J, Colomer C, Moliner B, O’Valle M, Ugart P, et al. Feasibility, safety and efficacy of transauricular vagus nerve stimulation in a cohort of patients with disorders of consciousness. Brain Stimulat. 2020;13(2):427–9.