Auricular Vagal Neuromodulation Therapy (AVNT) significantly increases vagus nerve activity in healthy subjects [test template]

Published in: Journal Name


Lorem ipsum dolor sit amet, consectetur adipiscing elit. In ut dolor ac lectus mollis accumsan non nec erat. Mauris sit amet tortor non ipsum rutrum commodo. Maecenas finibus sagittis enim, eget fermentum nunc vehicula at. Sed tempus mollis massa vel tempor. Vivamus luctus lacus a leo bibendum consectetur. Nulla ac pellentesque dolor, in ornare erat. Nulla semper varius condimentum. Vestibulum dapibus auctor dui nec congue. Proin malesuada commodo dolor, et aliquet nisi bibendum id. Nullam nec tristique purus, posuere pretium nisl. Aliquam at tincidunt ligula. Nulla venenatis aliquet cursus. Donec viverra placerat neque, et vulputate elit facilisis vitae. Vivamus vel imperdiet eros.

Cras ut accumsan eros. Morbi tempus nulla a metus vehicula, at pretium augue aliquet. Mauris ac nisi vitae arcu consectetur fringilla. Donec aliquet, mauris ac venenatis mollis, nibh justo varius lorem, a lobortis odio dui ac ipsum. Suspendisse sed dictum enim. Nunc sollicitudin dui ut sem varius, eget venenatis lectus rutrum. Proin sed dapibus lectus, id interdum turpis. Ut lobortis, diam euismod luctus tristique, sem turpis tristique massa, in finibus nibh mi a ligula. Mauris vitae turpis vestibulum felis aliquet congue eu nec quam. Donec cursus sodales diam eu accumsan. Donec semper est at felis dignissim posuere. Phasellus sed lacus quis mauris finibus viverra.

Study Design

Randomised Placebo Controlled

Study 1: Two-stages cross-over study compared the effects of Nurosym neuromodulation (tragus) and placebo stimulation (earlobe) on heart rate variability (HRV). Each participant underwent two visits, with the order of stimulation and placebo control randomised. Each visit comprised three phases: a 5-minute baseline period, a 5-minute stimulation period, and a 5-minute recovery period. During the stimulation period, participants received either Nurosym neuromodulation or placebo stimulation, while the effects of stimulation were assessed during the recovery period. Physiological data, including electrocardiogram (ECG) and respiratory data, were continuously recorded throughout the visits.

Statistical analyses were performed to compare the effects of Nurosym neuromodulation and placebo stimulation in Study 1 assessed parameter-specific effects of neuromodulation in Study 2. Various HRV parameters, including time-domain and frequency-domain indices, were analysed to evaluate the effects of stimulation on cardiac autonomic function.

Why is it important

The vagus nerve is a key component of the autonomic nervous system and plays a strategic role in the human body, acting as a bridge between the brain and various internal organs. It is involved in the regulation of many major systems, the activity of which is a marker of the parasympathetic nervous system and significantly inversely correlates with markers of inflammation. Therefore, increased cardiac vagal activity is proportionally associated with health, well-being, relaxation, and even emotions such as empathy. Conversely, decreased cardiac vagal activity is linked with risk factors such as morbidity, mortality, and stress. Nurosym, as a neuromodulation tool targeting vagal afferents, may have a powerful input to the brain and can influence a large number of physiological processes.


Both the low frequency (LF) and high frequency (HF) components of heart rate variability serve as indicators of vagus nerve activity. The LF component reflects a blend of sympathetic and parasympathetic modulation, while the HF component, detected at 0.15–0.40 Hz, is specifically associated with parasympathetic modulation of heart rate. The study indicated an increase in the activity of the vagus nerve by approximately 61%, as measured by the HF component (*p < 0.0017, Nurosym neuromodulation vs. placebo stimulation), demonstrating significant effectiveness.

End points

Study 1: The Nurosym neuromodulation group was associated with significantly higher measures of cardiac vagal activity compared to placebo group. Notably, these effects persisted beyond the stimulation period, indicating a carry-over effect. Moreover, baseline LF/HF ratio emerged as a significant predictor of individual response to the vagus nerve neuromodulation, showing that individuals with higher sympathetic activity experienced greater autonomic benefits from the intervention.


Nurosym vagus nerve neuromodulation activates the parasympathetic nervous system through the vagus nerve, acting as a calming messenger in the body. Nurosym relays information to central vagal projections in the brain stem and higher centres, which, in turn, provide the efferent neural signal to the heart, ensuring the balance between the sympathetic and parasympathetic nervous systems. This connection makes it relevant in the treatment of many diseases, including neurodegenerative diseases, chronic pain, inflammation, and cardiovascular diseases.


Vagus nerve, Neuromodulation, Heart rate variability (HRV), Parasympathetic nervous system, Sympathetic nervous system, Autonomic nervous system, Nurosym, Placebo-controlled study, Randomized controlled trial, Cardiac vagal activity, LF/HF ratio, Neurodegenerative diseases, Chronic pain, Inflammation, Cardiovascular diseases, ECG (Electrocardiogram), Respiratory data, Randomised cross-over study, Study design, Statistical analyses.

Learn more about Nurosym and how it can help you.

Go to Clinical Evidence