Best In Class

Nurosym is pioneering a new class of technology that uses bioelectrical signals targeted to neural circuits of organs, treating disease without surgery or drugs. As a clinically focused company founded on science, Nurosym’s primary focus is developing evidence based noninvasive drug-free neuromodulation.

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How does Nurosym Work

The Mechanisms of Nurosym Neuromodulation

Nurosym sends patented electrical impulses to the brain via the Vagus Nerve, which leads to:

Activation of the parasympathetic nervous system and improved HRV

  • Stress
  • Depression, Anxiety
  • Insomnia
  • Athletic recovery
  • Ageing & Longevity

The parasympathetic nervous system is the body’s internal relaxation & rest mechanism. HRV is an indicator of Vagus Nerve activity. Improving these parameters of HRV indicates targeted stimulation of the vagus nerve and activation of specific self-repair mechanisms of body & mind.

In a clinical trial, a one-hour session of Nurosym favourably altered all three parameters of Heart Rate Variability (HRV), when compared to a placebo.

Figure (a) shows High Frequency HRV is significantly increased ('p=0.001). Figure (b) shows Low-Frequency HRV is significantly decreased ('P=0.001). Figure (c) shows the ratio of LF to HF is significantly decreased (*p=0.002).

Source

Parasym clinical study

Improved Fatigue, Brain fog, Depression & Pain

  • Chronic Fatigue Syndrome (ME/CFS)
  • Stress & Anxiety
  • Depression
  • Athletic recovery
  • Productivity
  • Respiratory conditions

In a study of patients experiencing chronic fatigue symptoms after Covid-19 infection, approximately 40% of the participants showed positive responses to treatment involving Nurosym neuromodulation, as evidenced by improvements in fatigue, brain fog, and widespread pain. Improvement in long COVID symptoms, such as persistent fatigue, brain fog, and respiratory issues, can enhance quality of life and reduced disability.

Source

Parasym clinical study

Reduced Inflammation

  • Ageing & Longevity
  • Muscle pain
  • Chronic pain
  • Cardiac Conditions (AF, HF, Hypertension)
  • Mental health conditions
  • Autoimmune conditions
  • Post-viral syndromes (Long-Covid, Lyme Disease)
  • IBS & other GI symptoms

Inflammation throughout the body and brain contributes to disease development, progression, ageing, and mental health problems.

In a randomised controlled trial of Nurosym neuromodulation, inflammatory cytokines were significantly lower in the group that received low-level transcutaneous vagus nerve stimulation compared to the sham group at the end of 3 months.

The figure presents the changes in two inflammatory biomarkers - Cytokines: Tumor necrosis factor (TNF)‐α and Interleukin (IL)‐8.

Source

Parasym clinical study

Fatigue and Energy

  • Chronic Fatigue Syndrome (ME/CFS)
  • Productivity
  • Social functioning
  • Brain Fog
  • Sleep quality
  • Resilience to stress
  • Pain perception reduction
  • Long-Covid symptoms
  • Anti-ageing & longevity

Nurosym neuromodulation has shown a positive effect on fatigue by modulating the autonomic nervous system, contributing to improved energy levels and reduced feelings of exhaustion.

In the study, patients reported sustained improvement even one week after discontinuing the treatment, highlighting the potential of Nurosym for lasting relief from fatigue-related issues.

Source

Parasym clinical study

Depression and Mood

  • Memory & cognitive enhancement
  • Productivity
  • Brain Fog
  • Alzheimer’s & Dementia
  • Social functioning
  • Long-Covid

Nurosym neuromodulation decreased depression symptoms & improved mood in only 5 days of treatment.

The Parasym study revealed that a ten-day treatment regimen of Nurosym led to significant improvements in participants, alleviating chronic symptoms of depression and brain fog.

Source

Parasym clinical study

Improved Memory and Learning

  • Chronic Fatigue Syndrome (ME/CFS)
  • Long-Covid
  • Alzheimer’s & Dementia
  • Depression
  • Ageing & Longevity
  • Cognitive enhancement

Improved memory

Nurosym improves memory on learning tasks in comparison to placebo. (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.

Better learning

Nurosym paired with training improved performance on speed and decoding learning task measures in comparison to placebo. Nurosym neuromodulation significantly improved speed on the Automaticity learning task compared to controls. Nurosym neuromodulation also significantly improved percent correct on the Decoding learning task as compared to controls. ∗p < 0.05.

Source

Parasym clinical study

POTS Symptoms

  • Decreased inflammation
  • Improved heart rate & rythm regulation
  • Recuded risk of cardiovascular complications
  • Post-trauma recovery
  • Arrhythmias mitigation
  • Oxygen level increase

After two months of using Nurosym therapy, the active group experienced a significant reduction in postural tachycardia syndrome (POTS) compared to the sham group, as observed through heart rate variability analyses. Additionally, the active group showed lower levels of anti-autonomic autoantibodies (specifically α1-AR and β1-AR), indicating a potential improvement in autonomic function and a reduction in inflammation.

Source

Parasym clinical study

Blood Vessel Flexibility and Circulation

  • Oxygen and nutrient delivery to tissues
  • Organ function
  • Blood clots risk reduction
  • Varicose veins
  • Vascular disease risk reduction
  • Fatigue

Nurosym has demonstrated the ability to enhance blood circulation compared to a placebo.

This improvement in blood circulation, or perfusion rate, is crucial for efficiently supplying oxygen and nutrients to tissues while removing waste products.

Such enhancements contribute to overall health and longevity by optimizing blood supply to various organs.

Source

Parasym clinical study

Learn more about Nurosym research studies

Go to parasym.co

Meet the Doctors

Dr. Elisabetta Burchi, MD, MBA

Translational research lead at Parasym

A practicing doctor of psychiatry, Elisabetta has an MBA from INSEAD Business School, and experience in direct patient care, neuroscience research, communication and management. Dr. Burchi is a physician-scientist, working with Parasym in clinical affairs with a track record of publishing in the most important scientific journals such as The Lancet, writing successful grant proposals for the NIH, and leading the production of editorial, clinical, regulatory and promotional material in collaborative multidisciplinary teams. Dr. Burchi has also coordinated clinical trials and implemented a tele-medicine practice which received a certification of excellence among more than 100,000 professionals.

Real Experiences

Patient Stories

Watch real stories of people who have used Nurosym and hear about how it has changed their lives.

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ARE YOU A RESEARCHER?

Collaborate with us

If you are a researcher interested in collaboration opportunities, reach out to discuss further. We welcome inquiries and look forward to exploring potential partnerships in our shared field of interest.

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ARE YOU A PATIENT?

Ask your Doctor about Nurosym

Ask you doctor or a licensed healthcare practitioner about Nurosym and get on the road to the health you deserve, and most importantly, feeling like yourself again. If you do not have a doctor or would like to consult with a telehealth group, contact us here.

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Are you a healthcare professional?

Contact us with questions to learn more.

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61% increase in Vagus Nerve Activity & improved Heart Rate Variability

Heart Rate Variability (HRV) is a biomarker of Parasympathetic “rest and digest” system activation, indicating a balanced nervous system often associated with increased vagus nerve activity. In clinical trials, a one-hour session of Nurosym favourably altered three key parameters of Heart Rate Variability (HRV), when compared to placebo. These findings indicate an activation of the parasympathetic "rest and digest" system, coupled with a decrease in the "fight or flight" response.

Health implications:
  1. Stress
  2. Anxiety
  3. Exercise recovery
  4. Longevity
  5. Dysautonomia
Source:

Parasym clinical study

Figure (A) shows High Frequency HRV is significantly increased (*p=0.001). Figure (B) shows Low Frequency HRV is significantly decreased (*P=0.001). Figure (C) shows the ratio of LF to HF is significantly decreased (*p=0.002). It suggests a greater shift towards the parasympathetic side during Nurosym neuromodulation, indicating a more pronounced relaxation response.

(Figure A, B, C, D) The autonomic function response, Nurosym Neuromodulation favourably altered all HRV parameters (A: HF, B: RMSSD, C: pRR50, D: SDRR). Better effects were observed in people with a poorer baseline HRV ratio. Memory effect was observed, meaning HRV remains elevated after neuromodulation was stopped.

61% improvement in inflammation

Inflammation throughout the body and brain can contribute to diseases development, premature ageing and mental health problems.

Cytokines are the main biomarkers (measures) of inflammation in the body.

In a randomised controlled trial, inflammatory cytokines were significantly lower in the group that received Nurosym neuromodulation compared to the placebo group at the end of 3 months. The study presented the changes in two inflammatory biomarkers: Tumor necrosis factor (TNF)‐α and Interleukin (IL)‐8 after Nurosym therapy.

Health implications:
  1. Cardiovascular health (AF, HF, Hypertension)
  2. Anti-ageing & Longevity
  3. Muscle pain
  4. Chronic pain
  5. Mental health conditions
  6. Autoimmune conditions (e.g. Rheumatoid Arthritis, Crohn’s Disease)
  7. Post-viral syndromes (Long-Covid, Lyme Disease)
  8. IBS, GERD & other GI symptoms
Source:

Parasym clinical study

(Figure A, B) In a three-month study employing the Nurosym device for heart failure patients, notable improvements (*P < 0.05) were noted in inflammatory biomarkers: (A) Tumor Necrosis Factor (TNF)‐α exhibited a ~23% reduction, while (B) Interleukin (IL)‐8 showed a marked ~61.3% reduction. The investigation specifically targeted participants with elevated baseline inflammation levels.

Reduced fatigue & increased energy

Significant improvement in fatigue scores after treatment (D0 vs. D10, p < 0.0001).

Fatigue was measured using the Pichot Fatigue Scale. Participants reported that the improvements in fatigue remained 1 week after stopping the treatment.

Source:

Parasym clinical study

(Figure) In the study fatigue was assessed using of the Pichot fatigue scale scores during treatment (D0: day 0, D5: day 5 and D10: day 10). The results revealed a substantial reduction in fatigue, registering approximately 48% and higly significant improvment (D0 vs. D10, p < 0.0001) after Nurosym neuromodulation treatment. The individual values and the median are shown.

45% improvement in depression symptoms & improved mood

Nurosym neuromodulation decreased depression symptoms & improved mood in only 5 days of treatment.

The Parasym study revealed that a ten-day treatment regimen of Nurosym led to significant improvements in participants, alleviating chronic symptoms of depression and brain fog.

Health implications:
  1. Memory & cognitive enhancement
  2. Productivity
  3. Brain Fog
  4. Alzheimer’s & Dementia
  5. Social functioning
  6. Long-Covid
Source:

Parasym clinical study

(Figure) The figure shows the evolution of the Beck depression scale (D0: day 0, D5: day 5 and D10: day 10). The results showed a noticeable improvement in mood, registering approximately 45% on the Beck Depression Scale. The individual values and the median are shown.

13% improvement in sleep

Parasym study involving daily Nurosym neuromodulatiom demonstrated significant improvements in global sleep scores over a 2-week period. In the group with an active neuromodulation program, there was a ~13% improvement in global sleep scores. Nurosym therapy may address sleep concerns in community-dwelling adults and it exhibits harmless effects on sleep improvement compared to drug-treatmeant.

Health implications:
  1. Energy
  2. Productivity
  3. Chronic disease & pain reduction
  4. Brain Fog
  5. Chronic Fatigue Syndrome (ME/CFS)
  6. Ageing & Longevity
  7. Memory & Cognitive enhancement
  8. Stress resilience
Source:

Parasym clinical study

(Figure) The study assessed changes in global sleep scores (PSQI) in 68 individuals who underwent 14 days of either active Nuorsym neuromodulaton (blue and red lines) or sham stimulation (green and orange lines). The predictions, shown with 95% confidence intervals, considered various factors like sleep scores, time, group, phase, age, gender, and their interactions. tVNS: transcutaneous vagus nerve stimulation

30% improvement in memory & learning

Nurosym research explores enhancements in memory and neuroplasticity. Improved cognitive function is correlated with the parasympathetic nervous system, whereas cognitive decline is associated with the sympathetic nervous system.

Health implications:
  1. Cognitive enhancement and performance
  2. Memory function
  3. Problem-solving skills
  4. Alzheimer’s & Dementia
  5. Anti-ageing & Longevity
  6. Productivity
  7. Dementia risk reduction
Source:

Parasym clinical study

(Figure A, B) Nurosym improves memory on learning tasks in comparison to placebo. (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.

(Figure) Nurosym neuromodulation paired with training significantly (*p < 0.05) improved speed performence on the Automaticity learning task compared to placebo controls. Nurosym neuromodulation also significantly (∗p < 0.05) improved percent correct on the Decoding learning task as compared to controls.

40% improvement in Long-Covid symptoms (fatigue, brain fog, pain)

In a study of patients experiencing chronic fatigue symptoms after Covid-19 infection, approximately 40% of the participants showed positive responses to treatment involving Nurosym neuromodulation, as evidenced by improvements in fatigue, brain fog, and widespread pain. Improvement in long COVID symptoms, such as persistent fatigue, brain fog, and respiratory issues, can enhance quality of life and reduced disability.

Health implications:
  1. Chronic Fatigue Syndrome (ME/CFS)
  2. Stress & Anxiety
  3. Depression
  4. Athletic Recovery
  5. Productivity
  6. Respiratory conditions
Source:

Parasym clinical study

(Figure A) A very significant improvement was observed after 10 treatment sessions. (D0 vs. D10: p < 0.0001). Reserach evaluated our proprietary neuromodulation on those suffering with Long-COVID symptoms such as Fatigue, cognitive problems, Depression, Pain etc. Treatment starts after baseline measurement at Day 0 (D0), ending on D10, with follow up measurements one week later (D17).

40% reduction in POTS symptoms

After two months of using Nurosym therapy, the active group experienced a significant reduction in postural tachycardia syndrome (POTS) compared to the sham group, as observed through heart rate variability analyses. Additionally, the active group showed lower levels of anti-autonomic autoantibodies (specifically α1-AR and β1-AR), indicating a potential improvement in autonomic function and a reduction in inflammation.

Health implications:
  1. Decreased inflammation
  2. Improved heart rate & rythm regulation
  3. Recuded risk of cardiovascular complications
  4. Post-trauma recovery
  5. Arrhythmias mitigation
  6. Oxygen level increase
Source:

Parasym clinical study

50% improvement in blood vessel flexibility & improved circulation

Nurosym has demonstrated the ability to enhance blood circulation compared to a placebo. This improvement in blood circulation, or perfusion rate, is crucial for efficiently supplying oxygen and nutrients to tissues while removing waste products. Such enhancements contribute to overall health and longevity by optimizing blood supply to various organs.

Health implications:
  1. Oxygen and nutrient delivery to tissues
  2. Organ function
  3. Blood clots risk reduction
  4. Vascular disease risk reduction
  5. Varicose veins
  6. Fatigue
Source:

Parasym clinical study

(Figure (A, B, C): (A) Pseudo color images on dorsum of left hand during (1) baseline, (2) occlusion, and (3) Postocclusive reactive hyperemia (PORH) phase. Blue color represents lower, red represents higher perfusion rates. (B, C) Changes in blood perfusion measured over nail bed area, before and after Nurosym neuromodulation (B) and sham (placebo) stimulation (C). Markedly higher perfusion rate was seen after Nurosym neuromodulation