Nurosym

• Anxiety and Stress related conditions
• Chronic Fatigue Syndrome (CFS)/ Myalgic encephalomyelitis (ME) / Brain fog
• Irritable Bowel Syndrome (IBS)
• Sleep problems
• Depressive thoughts
• Digestive issues
• Inflammatory conditions
• Pain
• Memory & Attention problems
• Dysautonomia
• Postural Orthostatic Tachycardia Syndrome (POTS)
• Tinnitus
• Long-Covid
• Post-Viral Syndrome
• Fibromyalgia
• Heart Failure
• Atrial Fibrillation

These conditions & syndromes have been linked to autonomic nervous system imbalance and Vagus Nerve Impairment. Our latest research data also suggests Nurosym improves learning and short-term memory and cognition.

Nurosym also has been shown to promote relaxation, mood, sleep, healthy digestion, increased HRV, as well as to alleviate symptoms of stress, burnout, adrenal fatigue.

Parasym research is also investigating the impact of neuromodulation on athletic performance, muscle recovery, obesity, alcoholism and more.

If you’re not sure if Nurosym is for you, take our Vagus Nerve Impairment Assessment consult with your doctor or contact our medical support by clicking the Support icon at the bottom right of the page.

If you do not have a doctor you can contact, please reach out to our support and we’ll help connect you with the right person.

• Patients who have undergone surgery to cut the vagus nerve (cervical vagotomy);
• Patients diagnosed with severe bradycardia;
• Patients with a permanent (that cannot be removed before using Nurosym) implanted metallic or electronic device or jewellery at close proximity to the ear tragus;
• Pregnant women.

Below are listed situations that are also contraindications unless the patient receives a different medical opinion on the device use by their medical doctor and is under the supervision of a medical doctor while using the device. If you fall under one of these categories, your doctor might advise whether, in your specific case, the device is safe to use, potentially following certain precautions or under specific supervision:

• Patients with any active implanted device (including electronic and/or medical devices) e.g. cochlear implant, cerebral shunts, invasive vagus nerve stimulators, pacemakers2 or non-active but potentially interacting with the nervous system (e.g. metal implants);
• Patients with known severe coronary disease or recent myocardial infarction (within 5 years);
• Paediatric patients

1. Pregnant women have not been evaluated in clinical studies.
2. Both paediatric patients and patients with pacemakers have been enrolled in clinical studies with Parasym technology, and no device related adverse events or interferences have been observed so far in the clinical setting.

If you do not have a doctor you can contact, please reach out to our support and we’ll help connect you with the right person.

1. Improved HRV & activation of parasympathetic nervous system
   
   Health Implications:
   • Stress resilience
   • Depression, Anxiety
   • Insomnia & other sleep problems
   • Cardiovascular health
   • Athletic recovery
   • Ageing & Longevity
   See clinical results and learn more

   Parasympathetic nervous system is the body’s internal relaxation & self-repair mechanism.
   Vagus Nerve is its main component that connects to most organs and mediates signals to rest & heal.
   Heart Rate Variability (HRV) is an indicator of Vagus Nerve activity.
   Improving parameters of HRV indicate targeted stimulation of the vagus nerve and activation of specific self-repair mechanisms of body & mind.
   In clinical trials, one hour sessions of Nurosym favourably altered all three parameters of Heart Rate Variability (HRV), when compared to placebo.

   

   Source: Randomised, placebo controlled clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Cardiovascular and Translational Research Independent Clinical Study on Nurosym device, published in PLOS ONE

2. Reduced Inflammation
   
   Health Implications:
   • Cardiovascular health (AF, HF, Hypertension)
   • Ageing & Longevity
   • Muscle pain
   • Chronic pain
   • Mental health conditions
   • Autoimmune conditions (e.g. Rheumatoid Arthritis, Crohn’s Disease)
   • Post-viral syndromes (Long-Covid, Lyme Disease)
   • IBS, GERD & other GI symptoms
   See clinical results and learn more

   Inflammation throughout the body and brain contributes to diseases development, progression, ageing and mental health problems.
   Cytokines are the main biomarkers (measures) of inflammation in the body.
   In a randomised controlled trial, inflammatory cytokines were significantly lower in the group that received Nurosym neuromodulation compared to the placebo group at the end of 3 months.

   

   Source: Randomised, placebo controlled clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Journal of Cardiovascular Pharmacology,
   Randomised, placebo controlled clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Nature Reviews Cardiology

3. Improved cognitive functions
   
   Health Implications:
   • Brain Fog
   • Depression
   • Chronic Fatigue Syndrome (ME/CFS)
   • Long-Covid
   • Ageing & Longevity
   • Cognitive enhancement
   See clinical results for improved memory

   Nurosym improves memory on learning tasks in comparison to placebo.
   (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.

   

   Source: Randomised, placebo controlled clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Brain Stimulation

   See clinical results for enhanced learning

   Nurosym paired with training improved performance on speed and decoding learning task measures in comparison to placebo.
   Nurosym neuromodulation significantly improved speed on the Automaticity learning task compared to controls. Nurosym neuromodulation also significantly improved percent correct on the Decoding learning task as compared to controls. ∗p < 0.05.

   

   Source: Randomised, placebo controlled clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Brain Stimulation

4. Reduced fatigue & increased energy
   
   
   See clinical results

   There was a highly significant improvement in fatigue scores after treatment (D0 vs. D10, p < 0.0001). Fatigue was measured using the Pichot Fatigue Scale. Participants reported that the improvements in fatigue remained 1 week after stopping the treatment.

   

   Source: Clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Advances in Neurology and Neuroscience

5. Reduced Long Covid Symptom Intensity including Brain Fog & Fatigue
   
   
   See clinical results

   A very significant improvement was observed after 10 treatment sessions. (D0 vs. D10: p < 0.0001) We evaluated our proprietary neuromodulation on those suffering with Long-COVID symptoms such as Fatigue, cognitive problems, Depression, Pain etc.
   Treatment starts after baseline measurement at Day 0 (D0), ending on D10, with follow up measurements one week later (D17).

   

   Source: Clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Advances in Neurology and Neuroscience

6. Reduced depression & improved mood
   
   
   See clinical results

   Nurosym neuromodulation decreased depression symptoms & improved mood in only 5 days of treatment.
   The figure shows the evolution of the Beck depression scale scores during treatment (day 0, day 5 and day 10). The individual values and the median are shown.

   

   Source: Clinical study using Parasym proprietary neuromodulation technology, Independently evaluated and funded, published in Advances in Neurology and Neuroscience

7. Reduced Postural Orthostatic Tachycardia
   
   
   See clinical results

   Effect of active Nurosym neuromodulation vs sham (placebo) stimulation on the postural change in heart rate [Δ(heart rate)] at 2 months.
   The analysis showed that postural tachycardia (without a significant drop in blood pressure) was significantly less in subjects who received Nurosym neuromodulation compared to control (postural increase in heart rate 18±10 bpm vs. 32±14 bpm, respectively, p=0.016).

   

   Source: Randomised, placebo controlled clinical study using Parasym proprietary neuromodulation technology. Independently evaluated and funded, published in Journal of the American College of Cardiology

8. Improved blood circulation
   
   
   See clinical results

   Nurosym improves blood circulation in comparison to placebo.
   (A) Pseudo color images on dorsum of left hand during (1) baseline, (2) occlusion and (3). Postocclusive reactive hyperemia (PORH) phase. Blue color represents lower, red represents higher perfusion rates. (B, C) Changes in blood perfusion measured over nail bed area, before and after Nurosym neuromodulation (B) and sham (placebo) stimulation (C). Markedly higher perfusion rate was seen after Nurosym neuromodulation.

   

   Source: Randomised, placebo controlled clinical study using Parasym proprietary neuromodulation technology, Independently funded & evaluated, peer reviewed & published in Journal of Cardiovascular Pharmacology

Nurosym has partnered with 60+ research institutions, including UCLA and Harvard, to conduct clinical trials to validate the health benefits of Nurosym.

Our research is founded on these principles:

• Parasym’s studies are led by independent university experts, with no financial ties to us, unless explicitly mentioned.
• Our research is externally funded, ensuring unbiased and genuine results.
• We value transparency: All our trial findings (positive or otherwise) are open and accessible to everyone.
• We collaborate with distinguished physicians and scientists, ensuring the pinnacle of research quality.
• At Parasym, we adhere to the highest scientific standards, consistently achieving significant and trustworthy results in the most stringent tests. A large part of our clinical evidence comes from Randomised Placebo-controlled Clinical Trials, which are considered the highest standard of evidence.

Watch Dr Denef explain how to use Nurosym:

How to use Nurosym in a few steps:

1. Apply a bit of moisture on the tragus.
2. Wear the earpiece correctly on your left tragus, the cable should go over and behind your ear to keep the electrodes in place.
3. Turn on Nurosym
   Slowly increase energy level until you feel a light tingling sensation in your ear.
4. Notice how pleasant the sensation of neuromodulation feels. This is a signal that the current is flowing and that your parasympathetic nervous system is activated.
5. Sit or lie down with the device or perform daily activities while Nurosym works to strengthen your parasympathetic nervous system, decrease inflammation, oxidative stress and activate neuroplasticity to help you feel better.
6. Notice the sensations of calmness, relaxation, decreased stress, improved mood, more energy flowing into your body.
7. If you feel the sensation intensifies over time or you stop feeling it, adjust the energy level until you feel a light pleasant tingling sensation again.
8. Continue using Nurosym every day for 30-60 mins a day, preferably in the morning or split between morning after waking up and evening before sleep and enjoy better health & mood.

Gold standard in clinical research

• Nurosym is a certified medical device, with over $10M deployed in clinical trials, 60+ partner research organisations including Harvard, UCLU, 30+ published papers in leading journals covering our exciting and clinically significant results.
• This is why Nurosym is the leading non-invasive vagal neuromodulation system used in clinical neuromodulation research and now widely adopted.

Certified medical device with confirmed safety

• Exposing your nervous system and brain to untested electrical currents can put you at risk of a permanent damage to the brainstem and vagal nerve fibres, worsening your symptoms. Never use or suggest using DIY electrical current devices on your nervous system.
• Ensuring safety and efficacy requires extensive clinical studies that cost millions of dollars. This is why few Neuromodulation devices have been certified by health regulatory bodies as safe and effective.
• Beware of websites claiming to deliver benefits from uncertified treatments that present online reviews instead of clinical evidence. Carefully verify if a treatment you’re evaluating is registered as a medical device, which certifies it is safe and effective to use.
• When considering any health intervention, be sure to evaluate the status of certification, clinical evidence, warnings and seek advice of trusted health care professionals.
• Nurosym is one of a few registered neuromodulation based medical devices with safety confirmed by regulatory bodies in EU in Randomised Placebo Controlled Studies.
• Nurosym has a CE Mark in the EU and has been awarded FDA Non-Significant Risk Designation, which both confirm safety of our device.

Proven target activity

• In addition to safety, it is crucial to consider efficacy of various devices.
• The fact that a device is delivering a safe electrical current is not enough.
  It also needs to demonstrate that it indeed stimulates the right nerves and activates them. Triggering nerve action potential to fire requires precise waveform, frequency, wavelength and amplitude of electrical signal, as well as a specific stimulation site on the body closest to a particular branch of the vagus nerve.
• Without clinical data, we cannot know if a device is 1)actually stimulating the right neural pathways 2)not stimulating unintended neural pathway.
• Nurosym is demonstrated in clinical studies to stimulate the brainstem via the vagus nerve. Our patented waveform that exerts these effects has been developed over 8 years of laborious research with a total cost of over $10M.

Efficacy confirmed in Randomised Placebo Controlled Studies

• Many devices on the market claim benefits when combined with other practices such as meditation or breathing, which independently provide benefits such as relaxation, anxiety, mood, stress, sleep. This fact makes it hard to discern whether claimed benefits are due to the device itself or the additional practice.
• What’s more placebo effect is a strong influencer on benefits of numerous devices. Only randomised placebo controlled clinical studies can demonstrate whether a device benefit is independent of the placebo effect. Make sure to verify quality of evidence provided by the manufacturer.
• Nurosym has demonstrated benefits independent of other practices in a number of Randomised Placebo Controlled Studies.

Watch stories of recovery from patients worldwide on our Nurosym Stories page.

Yes, Nurosym is considered safe when used as intended.

Nurosym is a certified medical device (CE) in Europe. It has also received FDA Non-Significant Risk Designation in multiple studies in the US.

This means:

• It has been audited by medical regulators
• It is based on rigorous scientific evidence
• The benefits outweighs the risks
• It has demonstrated clinical efficacy
• It has strict quality management systems

Be sure to read the important safety information before use.

Nurosym has been evaluated in randomised placebo controlled clinical trials and now used widely with over 2M patient sessions and 0 serious adverse events have been reported.

Its safety has been confirmed in multiple clinical studies.

• We ship to all EU countries & UK and selected countries worldwide. If you can check out on our website, you can assume we can ship to you.
• We ship from Netherlands.
• Due to increased demand, orders are now temporarily processed and dispatched within 1-3 business days.
• You should receive your device within a few days after shipping depending on your location.
• There should not be any extra costs if you are inside the EU. If you are outside of the EU, you may be liable for import fees, which are out of our control.
• We know the impact Nurosym can have if used daily for 30 days, this is why we offer our guarantee. If you aren't happy after using Nurosym daily for 30 days, you can claim a full refund of your Nurosym Kit. This refund period is available 30 days after the date of purchase and expires the following week (37 days after the date of purchase).

If you try Nurosym daily for 30 days and aren’t happy with your results, we’ll send you a full refund of your Nurosym Kit.  No questions asked. 

Given the remarkable results Nurosym has had in clinical trials and with our customers around the world, we’re confident in its health-restoring effects. 

Our goal will always be to restore our collective health - restoring health for as many people as we can and in turn, restoring the health of our planet. 

If Nurosym doesn’t work for you for any reason, we’re happy to send you a refund. 

This refund period is available 30 days after the date of purchase and expires the following week (37 days after the date of purchase).

The refund will be issued once we receive your tracking code for the return.

To receive a refund, Contact us

Not sure Nurosym is for you? Contact our support

Important safety information

Nurosym might not be right for you. Before ordering, be sure to read about intended use, warnings, precautions and contraindications.

Consult with your doctor before using any medical intervention.
If you don’t have a doctor and would like to consult our team, contact us.