Nurosym

The following health conditions & syndromes have been linked to autonomic nervous system imbalance or Vagus Nerve Impairment:

• Chronic Fatigue Syndrome (CFS)/ Myalgic encephalomyelitis (ME) / Brain fog
• Irritable Bowel Syndrome (IBS)
• Anxiety and Stress related conditions
• Migraines
• Inflammatory conditions
• Insomnia
• Depression / Major Depressive Disorder (MDD)
• Long-Covid
• Postural Orthostatic Tachycardia Syndrome (POTS)
• Post-Viral Syndrome
• Autoimmune conditions (Rheumatoid Arthritis, Crohn's Disease)
• Fibromyalgia
• Epilepsy
• Tinnitus
• Heart Failure
• Atrial Fibrillation

What’s more, some research data suggests Nurosym also improves learning and short-term memory and cognition.

Nurosym also has been shown to promote relaxation, mood, sleep, healthy digestion, increased HRV, as well as to alleviate symptoms of stress, burnout, adrenal fatigue.

Research is also investigating the impact of neuromodulation on athletic performance, muscle recovery, obesity, alcoholism and more.

If you’re not sure if Nurosym is for you, take our Vagus Nerve Impairment Assessment
consult with your doctor or contact our medical support by clicking the Support icon at the bottom right of the page.

Contraindications

• Patients with an active implantable medical device, such as a cardiac pacemaker, hearing aid implant, or any implanted metallic or electronic device.
• Patients with a history of atherosclerotic cardiovascular disease, congestive heart failure (CHF), known severe coronary artery disease or recent myocardial infarction (within 5 years).
• Patients with diagnosed bradycardia.
• Patients who have had surgery to cut the vagus nerve in the neck (cervical vagotomy).
• Paediatric patients (under 18 years of age).
• Pregnant woment

If you are not sure if Nurosym is right for you, contact a doctor or a certified healthcare professional.

If you do not have a doctor you can contact, please reach out to our support and we’ll help connect you with the right person.

Nurosym sends patented electrical impulses to the brain via the Vagus Nerve, which leads to:

1. Activation of parasympathetic nervous system & Improved HRV

   1. In clinical trials, one hour sessions of Nurosym favourably altered three key parameters of Heart Rate Variability (HRV), when compared to placebo.

      These results show significant parasympathetic activation and reductions in the fight or flight response.

      

      Figure (a) shows High Frequence HRV is significantly increased ('p=0.001). Figure (b) shows Low Frequency HRV is significantly decreased ('P=0.001). Figure (c) shows the ratio of LF to HF is significantly decreased (*p=0.002).
      
      (Parasym clinical trial, 2022, PLOS ONE)

   2. Health Implications:

      1. Stress resilience
      2. Depression, Anxiety
      3. Insomnia & other sleep problems
      4. Cardiovascular health
      5. Athletic recovery
      6. Ageing & Longevity

1. Reduced Inflammation:

   1. Inflammation throughout the body and brain can contribute to diseases development, premature ageing and mental health problems.

      Cytokines are the main biomarkers (measures) of inflammation in the body.

      In a randomised controlled trial, inflammatory cytokines were significantly lower in the group that received Nurosym neuromodulation compared to the placebo group at the end of 3 months.

      

      The figure presents the changes in two inflammatory biomarkers: Tumor necrosis factor (TNF)‐α and Interleukin (IL)‐8.

      (Parasym clinical trial, Stavrakis et al., 2022, Journal of the American Heart Association)

   2. Health implications:

      1. Cardiovascular health (AF, HF, Hypertension)
      2. Ageing & Longevity
      3. Muscle pain
      4. Chronic pain
      5. Mental health conditions
      6. Autoimmune conditions (e.g. Rheumatoid Arthritis, Crohn’s Disease)
      7. Post-viral syndromes (Long-Covid, Lyme Disease)
      8. IBS, GERD & other GI symptoms

1. Improved cognitive functions

   Vagus Nerve Impairment, low parasympathethic activity & inflammation are often associated with cognitive problems, such as brain fog, fatigue, depression.

   Nurosym has been shown to provide improvements in cognition & mood.

2. Improved memory

   Nurosym improves memory on learning tasks in comparison to placebo.

   (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.

   

   (Parasym clinical trial, Thakkar et al., 2021, psyarxiv)

   
   
3. Better learning

   Nurosym paired with training improved performance on speed and decoding learning task measures in comparison to placebo.

   

   Nurosym neuromodulation significantly improved speed on the Automaticity learning task compared to controls. Nurosym neuromodulation also significantly improved percent correct on the Decoding learning task as compared to controls. ∗p < 0.05.

   (Parasym clinical trial, Thakkar et al., 2020, Brain Stimulation)

4. Health implications:
   1. Brain Fog
   2. Depression
   3. Chronic Fatigue Syndrome (ME/CFS)
   4. Long-Covid
   5. Alzheimer’s & Dementia
   6. Ageing & Longevity
   7. Cognitive enhancement

Does Nurosym work?

Yes, Nurosym is supported by clinical evidence.

What can Nurosym do for me?

Clinical research has shown Nurosym provides the following benefits confirmed by millions of patient sessions:

• Reduced brain fog
• Improved memory & cognition
• Reversed mechanisms causing fatigue
• Reduced fight or flight response and stress
• Reduced Depression/Anxiety
• Improved mood
• Improved Heart Rate Variability (HRV)
• Reduced post-viral symptoms
• Improved sleep
• Decreased inflammation & oxidative stress
• Reduced gut symptoms

Scientific method & research principles

Nurosym has partnered with 60+ research institutions, including UCLA and Harvard, to conduct clinical trials to validate the health benefits of Nurosym.

Our research is founded on these principles

• Parasym's studies are led by independent university experts, with no financial ties to us.
• Our research is externally funded, ensuring unbiased and genuine results.
• We value transparency: All our trial findings (positive or otherwise) are open and accessible to everyone.
• We collaborate with distinguished physicians and scientists, ensuring the pinnacle of research quality.
• At Parasym, we adhere to the highest scientific standards, consistently achieving significant and trustworthy results in the most stringent tests. A large part of our clinical evidence comes from Randomised Placebo-controlled Clinical Trials, which are considered the highest standard of evidence.

Clinical Evidence

watch stories of recovery from patients worldwide on our Nurosym Stories page.

Yes, Nurosym is considered safe when used as intended.

Nurosym is a certified medical device (CE) in Europe. It has also received FDA Non-Significant Risk Designation in multiple studies in the US.

This means:

• It has been audited by medical regulators
• It is based on rigorous scientific evidence
• The benefits outweighs the risks
• It has demonstrated clinical efficacy
• It has strict quality management systems

Be sure to read the important safety information before use.

Nurosym has been evaluated in randomised placebo controlled clinical trials and now used widely with over 2M treatment sessions and 0 serious adverse events have been reported.

Its safety has been confirmed in multiple clinical studies.

Watch Dr Denef explain how to use Nurosym:

How to use Nurosym in a few steps:

1. Apply a bit of moisture on the tragus.
2. Wear the earpiece correctly on your left tragus, the cable should go over and behind your ear to keep the electrodes in place.
3. Turn on Nurosym
   Slowly increase energy level until you feel a light tingling sensation in your ear.
4. Notice how pleasant the sensation of neuromodulation feels. This is a signal that the current is flowing and that your parasympathetic nervous system is activated.
5. Sit or lie down with the device or perform daily activities while Nurosym works to significantly increase your autonomic tone, increasing parasympathetic (rest and digest) activity and decreasing sympathetic nervous system (fight or flight) activity, decrease inflammation, oxidative stress and activate neuroplasticity to allow the brain to form beneficial and adaptive neural pathways.
6. Notice the sensations of calmness, relaxation, decreased stress, improved mood, and increased energy.
7. If you feel the sensation intensifies over time or you stop feeling it, adjust the energy level until you feel a light pleasant tingling sensation again.
8. Continue using Nurosym every day for 30-60 mins a day, preferably in the morning or split between morning after waking up and evening before sleep and enjoy better health & mood.

Gold standard in clinical research

• Nurosym is a certified medical device, with over $10M deployed in clinical trials, 60+ partner research organisations including Harvard, UCLU, with published papers in leading peer reviewed journals covering our exciting and clinically significant results.
• This is why Nurosym is the leading non-invasive vagal neuromodulation system used in clinical neuromodulation research and now widely adopted.

Certified medical device with confirmed safety

• Exposing your nervous system and brain to untested electrical currents can put you at risk of a permanent damage to the brainstem and vagal nerve fibres, worsening your symptoms. Never use or suggest using DIY electrical current devices on your nervous system.
• Ensuring safety and efficacy requires extensive clinical studies that cost millions of dollars. This is why few Neuromodulation devices have been certified by health regulatory bodies as safe and effective.
• Beware of websites claiming to deliver benefits from uncertified treatments that present online reviews instead of clinical evidence. Carefully verify if a treatment you’re evaluating is registered as a medical device, which certifies it is safe and effective to use.
• When considering any health intervention, be sure to evaluate the status of certification, clinical evidence, warnings and seek advice of trusted health care professionals.
• Nurosym is one of a few registered neuromodulation based medical devices with safety confirmed by regulatory bodies in EU in Randomised Placebo Controlled Studies.
• Nurosym has a CE Mark in the EU, which certifies the safety and effectiveness of neuromodulation delivered. Nurosym has also been designated Non-Significant Risk (NSR) by the FDA in multiple clinical studies.

Proven target activity

• In addition to safety, it is crucial to consider efficacy of the neuromodulation delivered.
• The fact that a device is delivering a safe electrical signal is not enough to be awarded certification. A neuromodulation device also needs to demonstrate that it indeed achieves significant clinical effects. In non-invasive vagal neuromodulation, this requires precise signal delivery via select nerve fibres to the brainstem.
• Clinical data is essential in determining that a device is achieving the target clinical effects and importantly not having dangerous or off target effects.
• Nurosym is supported by a body of clinical evidence that has been reviewed by health and regulatory authorities to ensure safety and effectiveness. The result is almost a decade and >$10M of clinical research, producing the safest and most studied non-invasive vagal neuromodulation system in the world.

Efficacy confirmed in Randomised Placebo Controlled Studies

• Other interventions on the market claim benefits when combined with other practices such as meditation or breathing, which independently provide benefits such as relaxation, anxiety, mood, stress, sleep. This fact makes it hard to discern whether claimed benefits are due to the intervention itself or the additional practice.
• Only randomised placebo controlled clinical studies can demonstrate whether a device benefit is independent of the placebo effect. Be sure to verify the quality of evidence when evaluating an intervention.
• Nurosym has demonstrated benefits independent of other practices in Randomised Placebo Controlled Clinical Trials.

• We ship to Europe, the UK and selected countries worldwide. If you can check out on our website, you can assume we can ship to you.
• We ship from Netherlands
• We ship within 24h
• You should receive your device within a few days after shipping depending on your location
• There should not be any extra costs if you are inside the EU. If you are outside of the EU, you may be liable for import fees, which are out of our control.
• We know the impact Nurosym can have if used daily for 30 days, this is why we offer our guarantee. If you aren't happy after using Nurosym daily for 30 days, you can claim a full refund. This refund period is available 30 days after the date of purchase and expires the following week (37 days after the date of purchase).

If you try Nurosym daily for 30 days and aren’t happy with your results, we’ll send you a full refund.  No questions asked. 

Given the remarkable results Nurosym has had in rigorously controlled clinical trials, we’re confident in its health-restoring effects.

Our goal will always be to restore our collective health - restoring health for as many people as we can and in turn, restoring the health of our planet. 

If Nurosym doesn’t work for you for any reason, we’re happy to send you a refund. 

This refund period is available 30 days after the date of purchase and expires the following week (37 days after the date of purchase).

The refund will be issued once we receive your tracking code for the return.

To receive a refund, Contact us

Not sure Nurosym is for you? Contact our support

Important safety information

Nurosym might not be right for you. Before ordering, be sure to read about intended use, warnings, precautions and contraindications.

Consult with your doctor before using any medical intervention.
If you don’t have a doctor and would like to consult our team, contact us.