I6: How Nurosym works

Nurosym sends patented electrical impulses to the brain via the Vagus Nerve, which leads to:

1. Activation of parasympathetic nervous system & Improved HRV

   1. Parasympathetic nervous system is the body’s internal relaxation & self-repair mechanism.

      Vagus Nerve is its main component that connects to most organs and mediates signals to rest & heal.

      Heart Rate Variability (HRV) is an indicator of Vagus Nerve activity.

      Improving parameters of HRV indicate targeted stimulation of the vagus nerve and activation of specific self-repair mechanisms of body & mind.

      In clinical trials, one hour sessions of Nurosym favourably altered all three parameters of Heart Rate Variability (HRV), when compared to placebo.

      

      Figure (a) shows High Frequence HRV is significantly increased ('p=0.001). Figure (b) shows Low Frequency HRV is significantly decreased ('P=0.001). Figure (c) shows the ratio of LF to HF is significantly decreased (*p=0.002).
      
      Source:
      Geng, D., Liu, X., Wang, Y., & Wang, J. (2022). The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people.

   2. Health Implications:

      1. Stress resilience
      2. Depression, Anxiety
      3. Insomnia & other sleep problems
      4. Cardiovascular health
      5. Athletic recovery
      6. Ageing & Longevity

1. Reduced Inflammation:

   1. Inflammation throughout the body and brain contributes to diseases development, progression, ageing and mental health problems.

      Cytokines are the main biomarkers (measures) of inflammation in the body.

      In a randomised controlled trial, inflammatory cytokines were significantly lower in the group that received Nurosym neuromodulation compared to the placebo group at the end of 3 months.

      

      The figure presents the changes in two inflammatory biomarkers: Tumor necrosis factor (TNF)‐α and Interleukin (IL)‐8.

      Source:
      Stavrakis, S., Elkholey, K., Morris, L., Niewiadomska, M., Asad, Z. U. A., & Humphrey, M. B. (2022). Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial. Journal of the American Heart Association

   2. Health implications:

      1. Cardiovascular health (AF, HF, Hypertension)
      2. Ageing & Longevity
      3. Muscle pain
      4. Chronic pain
      5. Mental health conditions
      6. Autoimmune conditions (e.g. Rheumatoid Arthritis, Crohn’s Disease)
      7. Post-viral syndromes (Long-Covid, Lyme Disease)
      8. IBS, GERD & other GI symptoms

1. Improved cognitive functions

   Vagus Nerve Impairment, low parasympathethic activity & inflammation are often associated with cognitive problems, such as brain fog, fatigue, depression.

   Nurosym has been shown to provide improvements on a few biomarkers of cognition & mood.

2. Improved memory

   Nurosym improves memory on learning tasks in comparison to placebo.

   (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.

   

   Source: Thakkar, V., Richardson, Z. A., Dang, A., & Centanni, T. (2021) Improvement of memory-based reading recall using transcutaneous auricular vagus nerve stimulation.

   
   
3. Better learning

   Nurosym paired with training improved performance on speed and decoding learning task measures in comparison to placebo.

   

   Nurosym neuromodulation significantly improved speed on the Automaticity learning task compared to controls. Nurosym neuromodulation also significantly improved percent correct on the Decoding learning task as compared to controls. ∗p < 0.05.

   Source: Thakkar, V. J., Engelhart, A. S., Khodaparast, N., Abadzi, H., & Centanni, T. M. (2020). Transcutaneous auricular vagus nerve stimulation enhances learning of novel letter-sound relationships in adults. Brain Stimulation

4. Health implications:
   1. Brain Fog
   2. Depression
   3. Chronic Fatigue Syndrome (ME/CFS)
   4. Long-Covid
   5. Alzheimer’s & Dementia
   6. Ageing & Longevity
   7. Cognitive enhancement