I3: Results from clinical studies

  1. Improved HRV & activation of parasympathetic nervous system

    Health Implications:
    • Stress resilience
    • Depression, Anxiety
    • Insomnia & other sleep problems
    • Cardiovascular health
    • Athletic recovery
    • Ageing & Longevity
    See clinical results and learn more

    Parasympathetic nervous system is the body’s internal relaxation & self-repair mechanism.
    Vagus Nerve is its main component that connects to most organs and mediates signals to rest & heal.
    Heart Rate Variability (HRV) is an indicator of Vagus Nerve activity.
    Improving parameters of HRV indicate targeted stimulation of the vagus nerve and activation of specific self-repair mechanisms of body & mind.
    In clinical trials, one hour sessions of Nurosym favourably altered all three parameters of Heart Rate Variability (HRV), when compared to placebo.

    Source: Geng, D., Liu, X., Wang, Y., & Wang, J. (2022). The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people.

  2. Reduced Inflammation

    Health Implications:
    • Cardiovascular health (AF, HF, Hypertension)
    • Ageing & Longevity
    • Muscle pain
    • Chronic pain
    • Mental health conditions
    • Autoimmune conditions (e.g. Rheumatoid Arthritis, Crohn’s Disease)
    • Post-viral syndromes (Long-Covid, Lyme Disease)
    • IBS, GERD & other GI symptoms
    See clinical results and learn more

    Inflammation throughout the body and brain contributes to diseases development, progression, ageing and mental health problems.
    Cytokines are the main biomarkers (measures) of inflammation in the body.
    In a randomised controlled trial, inflammatory cytokines were significantly lower in the group that received Nurosym neuromodulation compared to the placebo group at the end of 3 months.

    Source: Stavrakis, S., Elkholey, K., Morris, L., Niewiadomska, M., Asad, Z. U. A., & Humphrey, M. B. (2022). Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial. Journal of the American Heart Association

  3. Improved cognitive functions

    Health Implications:
    • Brain Fog
    • Depression
    • Chronic Fatigue Syndrome (ME/CFS)
    • Long-Covid
    • Alzheimer’s & Dementia
    • Ageing & Longevity
    • Cognitive enhancement
    See clinical results for improved memory

    Nurosym improves memory on learning tasks in comparison to placebo.
    (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.

    Source: Thakkar, V., Richardson, Z. A., Dang, A., & Centanni, T. (2021) Improvement of memory-based reading recall using transcutaneous auricular vagus nerve stimulation.

    See clinical results for enhanced learning

    Nurosym paired with training improved performance on speed and decoding learning task measures in comparison to placebo.
    Nurosym neuromodulation significantly improved speed on the Automaticity learning task compared to controls. Nurosym neuromodulation also significantly improved percent correct on the Decoding learning task as compared to controls. ∗p < 0.05.

    Source: Thakkar, V. J., Engelhart, A. S., Khodaparast, N., Abadzi, H., & Centanni, T. M. (2020). Transcutaneous auricular vagus nerve stimulation enhances learning of novel letter-sound relationships in adults. Brain Stimulation

  4. Reduced fatigue & increased energy

    See clinical results

    There was a highly significant improvement in fatigue scores after treatment (D0 vs. D10, p < 0.0001). Fatigue was measured using the Pichot Fatigue Scale. Participants reported that the improvements in fatigue remained 1 week after stopping the treatment.

    Source: Verbanck, P., Clarinval, A. M., Burton, F., Corazza, F., Nagant, C., & Cheron, G. (2021). Transcutaneous Auricular Vagus Nerve Stimulation (tVNS) can Reverse the Manifestations of the Long-COVID Syndrome: A Pilot Study. Frontiers in Psychiatry

  5. Reduced Long Covid Symptom Intensity including Brain Fog & Fatigue

    See clinical results

    A very significant improvement was observed after 10 treatment sessions. (D0 vs. D10: p < 0.0001) We evaluated our proprietary neuromodulation on those suffering with Long-COVID symptoms such as Fatigue, cognitive problems, Depression, Pain etc.
    Treatment starts after baseline measurement at Day 0 (D0), ending on D10, with follow up measurements one week later (D17).

    Source: Verbanck, P., Clarinval, A. M., Burton, F., Corazza, F., Nagant, C., & Cheron, G. (2021). Transcutaneous Auricular Vagus Nerve Stimulation (tVNS) can Reverse the Manifestations of the Long-COVID Syndrome: A Pilot Study. Frontiers in Psychiatry

  6. Reduced depression & improved mood

    See clinical results

    Nurosym neuromodulation decreased depression symptoms & improved mood in only 5 days of treatment.
    The figure shows the evolution of the Beck depression scale scores during treatment (day 0, day 5 and day 10). The individual values and the median are shown.

    Source: Verbanck, P., Clarinval, A. M., Burton, F., Corazza, F., Nagant, C., & Cheron, G. (2021). Transcutaneous Auricular Vagus Nerve Stimulation (tVNS) can Reverse the Manifestations of the Long-COVID Syndrome: A Pilot Study. Frontiers in Psychiatry

  7. Reduced Postural Orthostatic Tachycardia

    See clinical results

    Effect of active Nurosym neuromodulation vs sham (placebo) stimulation on the postural change in heart rate [Δ(heart rate)] at 2 months.
    The analysis showed that postural tachycardia (without a significant drop in blood pressure) was significantly less in subjects who received Nurosym neuromodulation compared to control (postural increase in heart rate 18±10 bpm vs. 32±14 bpm, respectively, p=0.016).

    Source: Stavrakis, S., Cai, X., Morris, L., Matlock, H. G., Asad, Z. U., Yu, X., et al. (2023). Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial. Heart Rhythm

  8. Improved blood circulation

    See clinical results

    Nurosym improves blood circulation in comparison to placebo.
    (A) Pseudo color images on dorsum of left hand during (1) baseline, (2) occlusion and (3). Postocclusive reactive hyperemia (PORH) phase. Blue color represents lower, red represents higher perfusion rates. (B, C) Changes in blood perfusion measured over nail bed area, before and after Nurosym neuromodulation (B) and sham (placebo) stimulation (C). Markedly higher perfusion rate was seen after Nurosym neuromodulation.

    Source: Dasari, T. W., Csipo, T., Amil, F., Lipecz, A., Fulop, G. A., Jiang, Y., Samannan, R., Johnston, S., Zhao, Y. D., Silva-Palacios, F., Stavrakis, S., Yabluchanskiy, A., & Po, S. S. (2021). Effects of Low-Level Tragus Stimulation on Endothelial Function in Heart Failure With Reduced Ejection Fraction. Randomized Controlled Trial. Journal of Cardiac Failure