Nervous System Dysregulation: The Silent Pandemic You’ve Never Heard of
Millions worldwide suffer from chronic fatigue, anxiety, and digestive disorders, often finding little relief despite consulting multiple doctors and trying various treatments [1]. Experts are contributing this to an imbalanced nervous system.
Nervous system responses - Fight or Flight vs. Rest and Digest
Recent research shows that many of these persistent health issues stem from nervous system dysfunction [2]. Our bodies naturally manage stress using two key components:
The Sympathetic System (“fight or flight”) prepares us to handle threats and challenges. The Parasympathetic System (“rest and digest”) promotes healing and balance. Together, these systems keep us healthy and adaptable [3].
The impact of chronic stress
When faced with constant stress, the nervous system becomes overwhelmed. This leads to excess cortisol, inflammation, and damage to various organs, causing brain fog, fatigue, anxiety, and widespread health problems [4].
Restoring balance between systems
Rather than treating individual symptoms, restoring harmony between the sympathetic and parasympathetic systems is crucial. By doing so, the body’s natural healing mechanisms can function as intended, promoting overall well-being [4].
Understanding and addressing the nervous system today is unlocking new paths to lasting well-being and Nurosym is at the forefront with over a decade of empirical research and careful study of Vagus Nerve mechanisms.
What is the Vagus Nerve?
The vagus nerve plays a vital role in your body’s ability to maintain balance and manage stress. As a primary component of the parasympathetic nervous system, it helps regulate "rest and digest" functions that are critical for your well-being.
• Plays key role in relaxation: When the brain receives sensory information it uses the vagus nerve to carry activation signals to various organs, telling your body to relax [5].
• Maintains balance and homeostasis: The vagus nerve regulates vital functions such as heart rate, digestion, immune response, and emotional regulation in response to stress, maintaining homeostasis [5].
• Runs through the whole body: With a vast network of 100,000 distinct fibers, the vagus nerve influences multiple physiological processes. Even minor disruptions can have significant impacts, potentially leading to undesired symptoms ranging from anxiety and chronic fatigue, to heart palpitations, or even autoimmune conditions [6].
Supporting vagus nerve health can dramatically improve your body's stress response, resilience, and adaptability since so many health conditions can be linked to nervous system dysregulation [6].
Vagus Nerve Stimulation as a Pathway to Health
Vagus Nerve Stimulation (VNS) means sending targeted electrical signals to specific fibres of the vagus nerve to positively affect the body’s physical and mental state [7].
For decades, doctors have explored the potential of stimulating the vagus nerve to address a wide range of physical and mental health conditions.
How It Works
Similar to how a pacemaker regulates the heart, VNS sends electrical signals to specific vagus nerve fibers to restore normal nervous system function. This therapy has shown promise in treating conditions previously resistant to conventional treatments [7].
From surgery to the first non-invasive device
Initially, VNS required invasive surgery, making it accessible only for severe cases. However, in 2020, Nurosym released the first certified non-invasive device, capable of achieving similar effects, but eliminating the need for surgical procedures [8][9].
Nurosym in-house technology
Nurosym uses Auricular Vagal Neuromodulation Therapy (AVNT), targeting the tragus of the ear for effective and safe stimulation of vagus nerve fibers [9][10]. This approach was empirically developed for over a decade by our team of leading neurologists and clinical researchers to ensure high efficacy while minimizing side effects.
Clinical validation and research
The effectiveness of Nurosym has been confirmed through over 40 peer-reviewed studies with prestigious institutions, including Harvard, UCLA, and the NHS. Clinical results have shown measurable improvements, such as reduced inflammation and enhanced cardiac function [9].
Regulatory approval and accessibility
Nurosym has received CE certification as a medical device and can be purchased without a prescription, making it available for both patients and healthy individuals [9].
Adoption and medical community consensus
Tens of thousands of people now use Nurosym on a regular basis, and hundreds of healthcare professionals recommend it as part of clinical treatment protocols.
With Nurosym, you can harness the transformative power of the vagus nerve from the comfort of your own home. Backed by extensive research, we offer a 30-day money-back guarantee, so you can try Nurosym risk-free and take control of your health.
Benefits of Vagus Nerve Stimulation
Vagus nerve stimulation is FDA-approved treatment for epilepsy, migraines, and treatment resistant depression. It has also been clinically proven to relieve a host of different health conditions and symptoms including [11]:
- Chronic fatigue
- Reduced Heart Rate Variability (HRV)
- Depression
- Anxiety
- Digestive issues
- Respiratory issues
- Inflammatory conditions
- Cognitive impairment
- Low mood
- Chronic pain
- Migraines
- Sleep issues
The Importance of Precision in Vagus Nerve Stimulation
Despite popular opinions on social media, activating the vagus nerve in a correct way without side effects is not an easy task.
Imagine trying to tune an old-fashioned radio dial to a specific frequency. The radio has a broad range of stations, but only one frequency offers the clear, balanced sound you're looking for.
This analogy perfectly illustrates the challenges in vagus nerve stimulation (VNS) therapy. The vagus nerve has 60 fibers, each representing a specific frequency linked to various bodily functions.
The difficulty lies in targeting the correct fibers at the precise time and through the appropriate access points to achieve therapeutic effects without causing unwanted side effects [12].
Ensuring The Highest Quality Testing and Safety Standards
Since 2014, we've tried to better understand the complex and crucial role the vagus nerve plays in overall health.
Selective and safe vagus nerve stimulation has been at the core of our mission, given the nerve's extensive role and complex network of approximately 100,000 fibers.
- Anatomical complexity: The vagus nerve originates in the brainstem, extends through the neck, and connects to multiple organs. Nurosym has been rigorously tested not to impede fibers carrying important signals influencing everything from heart function to emotional well-being [13].
- Therapeutic targeting: Nurosym delivers electrical impulses only to specific fibers proven to produce targeted effects, thus capable of addressing conditions like epilepsy, depression, heart disease, and inflammatory disorders [13].
- Preventing side effects: Since the vagus nerve affects all major organs, incorrect stimulation can actually lead to side effects, such as palpitations. Nurosym is continuously tested across all key biomarkers and has recorded zero reports of serious adverse effects in study populations.
- Optimal access points: The auricular branch in the ear, composed mainly of sensory fibers, is a safer option of accessing the vagus nerve compared to the neck, which has a delicate mix of sensory and motor fibers. The tragus is especially effective for VNS, offering a high density of afferent fibers near the skin surface for precise, natural activation of the parasympathetic nervous system [14].
Modulation vs Stimulation
When it comes to the vagus nerve, more stimulation isn’t always better. Achieving effective results requires precision and careful control to avoid unintended consequences.
- Precision is Crucial: Like tuning a radio to the right frequency, vagus nerve stimulation needs to be adjusted to each person’s unique nervous system. The optimal settings vary day by day and between individuals. Excessive or imprecise stimulation can disrupt the nervous system and cause harmful side effects, even leading to permanent damage.
- Certified Medical Devices Matter: To ensure safety, only rigorously tested medical devices should be used for vagus nerve stimulation. Nurosym stands out as a certified device, having passed extensive safety studies and met stringent EU regulatory standards for quality manufacturing.
- Regulatory Validation: Nurosym has been evaluated as a Non-Significant Risk device in multiple clinical trials by the FDA, highlighting its commitment to safety.
- Tailored Modulation: With 45 adjustable energy levels, Nurosym provides precise control, allowing each user to customize settings for optimal effectiveness and nervous system balance.
Your vagus nerve is invaluable, and using a trusted, certified medical device like Nurosym ensures safe and effective modulation tailored to your individual needs.
Convenience without gel
Vagus nerve stimulation is now more convenient than ever, thanks to innovative technology that eliminates the need for messy conductivity gels.
- Problem with traditional methods: Normally, electrical stimulation requires a conductivity gel to counter the skin’s constantly changing electrical resistance. However, gels can be messy and inconvenient, especially for frequent use.
- Nurosym's technological solution: After a decade of clinical research, Nurosym developed a neuromodulation system that eliminates the need for gel. The technology uses a hypoallergenic, high-conductivity material that is both biocompatible and effective at transmitting current through the skin.
- Safe and effective: This advanced material ensures efficient current delivery while minimizing the risk of skin irritation or damage, offering a hassle-free experience for regular use.
Your vagus nerve is invaluable, and using a trusted, certified medical device like Nurosym ensures safe and effective modulation tailored to your individual needs.
The most clinically studied device
Nurosym is the most clinically studied non-invasive device for auricular vagal neuromodulation, offering cutting-edge technology that brings safe and effective vagus nerve modulation to your fingertips.
- Extensive Clinical Validation: Backed by over 40 peer-reviewed studies and 10 years of research in partnership with top institutions like Harvard, UCLA, and several NHS hospitals.
- First CE-Marked Device for Consumers: Nurosym is the first non-invasive auricular vagal neuromodulation device to receive CE certification and be available to the public, ensuring top-tier safety and quality.
- Proprietary Technology: Utilizes Auricular Vagal Neuromodulation Therapy (AVNT) to deliver patented micro-impulses to the left ear tragus, ensuring precise targeting of the vagus nerve.
- Superior Vagal Activation: Functional MRI studies confirm that targeting the tragus provides the most selective and effective vagus nerve stimulation, minimizing the risk of side effects or damage associated with less precise sites [15].
With Nurosym, you gain access to a proven, non-invasive solution for vagus nerve modulation, developed with years of research and the highest clinical standards. Experience safe, precise therapy right in the palm of your hand.
How to use Nurosym
Attach the earpiece and wear just like a headphone
Position the cable over and behind your ear to keep the earpiece in place
Activate Nurosym
When Nurosym is active you will feel a pleasant tingling on your tragus
Use for 30-60 minutes per day
Seamlessly integrate with non-intensive daily activities
Experience the benefits of using Nurosym
Nurosym Results from 30+ Clinical Trials
Vagus Nerve Activity
Long-Covid Symptoms
Fatigue, Brain Fog, GI Symptoms, Pain
Fatigue
Sleep
Inflammation
Depression Score
Heart Rate Variability
POTS Tachycardia
Oxidative Stress
Memory
Reading
Macrocirculation
Microcirculation
Attention Deficiency
Anxiety
Atrial Fibrillation
Heart Muscle Function
GI Symptoms
Patient Stories
Watch real stories of people who have used Nurosym and hear about how it has changed their lives.
GO TO STORIES- GBD 2019 Diseases and Injuries Collaborators. 2020. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 17;396(10258):1204-1222.
- Zanin A., Amah G., Chakroun S. et al. 2023. Parasympathetic autonomic dysfunction is more often evidenced than sympathetic autonomic dysfunction in fluctuating and polymorphic symptoms of "long-COVID" patients. Sci Rep 13, 825.
- Alshak M.N &, Das J.M. Neuroanatomy, Sympathetic Nervous System. [Updated 2023 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
- Bellocchi C., Carandina A., Montinaro B., et al. 2022. The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases. Int J Mol Sci. 23;23(5):2449.
- Kenny B.J., Bordoni B. 2024. Neuroanatomy, Cranial Nerve 10 (Vagus Nerve) [Updated 2022 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
- Breit S., Kupferberg A., Rogler G., Hasler G. 2018. Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders. Front Psychiatry.13;9:44.
- Howland R.H. 2014. Vagus Nerve Stimulation. Curr Behav Neurosci Rep. 1(2):64-73.
- Ben-Menachem E., Hellström K., Verstappen D. 2002. Analysis of direct hospital costs before and 18 months after treatment with vagus nerve stimulation therapy in 43 patients. Neurology. 24;59(6 Suppl 4):S44-7.
- A Ground-Breaking Clinical Trial Using Parasym™ Neuromodulation Device Opens Potential New Era of Treatment for Heart Failure.” Markets Insider, 21 April 2022. Link to article.
- Ear Clip Stimulation of Vagus Nerve Shows Promise as POTS Treatment (OU College of Medicine). Link to article
- Johnson R.L., Wilson C.G. 2018. A review of vagus nerve stimulation as a therapeutic intervention. J Inflamm Res. 16;11:203-213.
- Fitchett A., Mastitskaya S.& Aristovich K. 2021. Selective Neuromodulation of the Vagus Nerve. Front Neurosci; 15:685872.
- Bonaz B., Sinniger V. & Pellissier S. 2017. The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract. Front. Immunol. 8:1452.
- Muthulingam J.A., Olesen S.S., Hansen T.M., el al. 2021. Cervical transcutaneous vagal neuromodulation in chronic pancreatitis patients with chronic pain: A randomised sham controlled clinical trial. PLoS One. 26;16(2):e0247653.
- Frangos E., Ellrich J. & Komisaruk B. 2015. Non-invasive Access to the Vagus Nerve Central Projections via Electrical Stimulation of the External Ear: fMRI Evidence in Humans. Brain Stimulation, 8(3):624-636.
- Blanz S.L., Musselman E.D., Settell M.L. et al. 2023. Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect. J Neural Eng. 22;20(1):10.1088.
- Hartmann R., Schmidt F.M., Sander C., et al. 2019. Heart Rate Variability as Indicator of Clinical State in Depression. Front Psychiatry. 17;9:735.